Endocrine Abstracts

The A-ZIP/F-1 transgenic mouse is a model of lipoatrophic diabetes with severe insulin resistance, hyperglycemia and hyperlipidemia. Recently, a regulatory role of adipose tissue on adrenal gland function and blood pressure has been suggested. To further explore the importance of adipose tissue in the regulation of adrenal function and blood pressure, we studied this mouse model of lipodystrophy. A-ZIP/F-1 mice exhibit significantly elevated systolic and diastolic blood pressu...

Neural cells are isolated from forebrain of 14.5 days old mouse embryos. In selective conditions these cells cluster forming sphere-like structures – neurospheres (NSCs). NSCs are heterogeneous structures containing only 2–5% of stem cells and progenitors being reportedly capable to transdifferentiate. Initially, aim of this study is to establish optimal culture conditions prior to investigation of transdifferentiation capacity of transplanted NSCs in kidney and adre...